Virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how our bodies detect and respond to viruses and viral replication. The publication explains ...

Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and ...

A new study on fatty acid acylation, or attachment, patterns onto proteins in Caenorhabditis elegans, a type of roundworm, provides a foundation for future discoveries around protein function and its ...

Exploring the post-translational modifications of a key protein in Parkinson's disease, researchers uncover potential pathways for future therapies in neurodegenerative diseases in general.

As we age, the composition and function of proteins in the brain change, affecting how well our brain performs later in life—influencing memory, responsiveness, and the risk of neurodegenerative ...

"For histones, the time window for modifications is incredibly tight because their protein chains are very short," explains first author Denis Yudin, a doctoral student in Nenad Ban's lab. "NAC ...

N-terminal acetylation represents one of the most ubiquitous protein modifications in eukaryotic cells, with significant implications for protein stability, folding, and interactions. This covalent ...

Cardiovascular disease remains the leading cause of mortality worldwide, necessitating deeper insights into its molecular underpinnings beyond genetic predisposition. Epigenetic modifications, ...

Boston College researchers have used a mild charge of electricity to precisely modify proteins—a new and inexpensive tool that can be used to develop novel biotherapeutics and protein-based research ...

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, present a significant health challenge, affecting over 50 million people globally. One common feature of these diseases is the ...