The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling ...

When myelin breaks down, white matter in the brain deteriorates, a change commonly seen with aging. At the same time, microglia, the brain’s primary immune cells, can shift from protective responders ...

Tumor growth unfolds within a tumor microenvironment (TME) defined by metabolic–immune crosstalk. Emerging evidence indicates that cancer cells not only reprogram glycolysis but also alter amino acid, ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study led by ...

After treatment, the mice’s memories were essentially shunted back into a younger state. The researchers found that reprogrammed engrams displayed molecular behavior of more youthful cells. Using a ...

For decades, scientists have worked to peer deeper into the brain. They have wanted to see not just surface activity in the cortex but also the hidden layers beneath, such as the hippocampus, where ...

A mechanism underlying neutrophil reprogramming in brain cancers has been uncovered, illuminating potential therapeutic targets to stop their pro-cancer effect. Tumor-infiltrating neutrophils are ...

Your brain relies on glucose to function correctly. This means that your mind and focus may be impacted if your blood sugar dips too low and too often.